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生化制药厂的老板Franklin提供大量资金供让Susan McAlester博士研究抗老年痴呆症的药物。Susan和研究小组在设备精良的海底研究中心，提取鲨鱼脑中蛋白质，注入坏死的人类脑细胞。为了可以提取到更多的鲨鱼脑蛋白，Susan也同时加大了鲨鱼们的脑容量。这一举动让本来作为试验品的鲨鱼们变得更为强壮和聪明。鲨鱼专家Carter因和鲨鱼们朝夕相处时发现了鲨鱼们的异样，并向Susan提出了警告，却得到了Susan的无视。终于，在最后一次实验中，那些曾经沦为人类试验品的凶残鲨鱼们向人类展开报复……。Johnny is finally old enough to participate in Porkbelly's Annual Running of the Squirrels, but he has to get past his mom, who thinks it's too dangerous. Johnny, the twins and Mom realize it's Father's Day, and they don't have a gift. They try many disastrous attempts, making Dad wish they had never remembered.。